NEW YORK – Researchers have identified a compound in myrrh, one of the gifts presented to Jesus by the Three Wise Men, that they believe could be developed into a potent anticancer agent.
The compound, which kills cancer cells in the laboratory, shows particular promise for the prevention and treatment of breast and prostate cancer, according to the researchers.
The finding is the first to identify an anticancer compound in myrrh.
“It’s a very exciting discovery,” said Mohamed M. Rafi, co-researchers at Rutgers University in New Brunswick, New Jersey. “I’m optimistic that this compound can be developed into an anticancer drug,” he said.
The researcher cautions that the compound has not yet been tested in animals or humans.
The research. As part of a larger search for anticancer compounds from plants, the researchers obtained extracts from a particular species of myrrh plant (Commiphora myrrha) and tested it against a human breast tumor cell line (MCF-7) known to be resistant to anticancer drugs.
Research data indicated that the extract killed all of the cancer cells in laboratory dishes.
Further investigations to isolate the active component of the extract found it to be a unique and previously unknown compound belonging to a class called sesquiterpenoids, which are typically found in natural products.
Rafi indicated that an increasing number of compounds in this class have been identified as having cytotoxic properties against cancer cell lines, but none has reached the marketing stage.
The myrrh compound appears to kill cancer cells by inactivating a specific protein, called Bcl-2, which is overproduced by cancer cells, particularly in the breast and prostate, the researcher said.
Overproduction of this protein is believed to promote the growth of cancer cells and make cells more resistant to chemotherapy. As cancer is influenced by many mechanisms, the investigators are now in the process of trying to determine whether the compound also has other mechanisms of inhibitory action against cancer cells.
Moderate strength. The researcher estimates that the compound tested is 100 times less potent than paclitaxel. The compound appears to fall within the moderate strength range of other recently discovered phytochemicals (isolated from plants), including resveratrol (from grapes), genestein (from soy) lycopene (from tomatoes) and catechins (from tea).
The good news is that these compounds all come from food and are unlikely to be toxic to healthy cells, which could mean fewer side effects as a chemotherapy agent, the researcher said.
Rafi predicts that there may be other compounds in myrrh that are more potent than the current anticancer candidate though yet to be isolated from the plant.
Developing any anticancer drug from myrrh may take five to 10 years, said Rafi. Animal studies of the current compound are planned.
What is it? Myrrh is the dried resin obtained from one of several trees of the genus Commiphora. The bitter-tasting, fragrant resin has been used for thousands of years as an ointment, perfume, incense and embalming fluid.
As a medicinal compound, it has been used to kill pain, heal wounds and neutralize bad breath. There is some documentation that some ancient civilizations may have even used the plant to combat cancer.
Today, myrrh can be found in health food stores as an ingredient in natural toothpaste and mouthwash, where it is used as an alternative to fluoride to fight dental decay. It is also available in capsule form, as a tea, and as an extract.